De novo design of a macrocycle induced dimerization system for cellular control
Stephanie Hanna, Patrick J. Salveson, Basile I. M. Wicky, Madison Kennedy, Derrick R. Hicks, Carolina Möller, Suna Cheng, Xinting Li, Mohamad H. Abedi, Brian Coventry, Meerit Y. Said, Asim K. Bera, Alex Kang, Barry L. Stoddard, David A. Baker
This paper designs a chemically induced dimerization system using a de novo macrocycle and protein homodimer to control cellular processes.
Nature Communications · May 18, 2026Peer-reviewedBiochemistry