Author

Nicole M. Chumbler

Broad InstituteORCID 0000-0002-4806-5415Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2 Approach:deep learning· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Eric M. PearlmaniD· 2 shared Michaela Ellen MarshalliD· 2 shared Mihaela G. GadjevaiD· 2 shared Oscar A. NegróniD· 2 shared Serena AbbondanteiD· 2 shared Andrei LoasiD· 1 shared Ankush Tyagi· 1 shared Arne RietschiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

Eric M. PearlmanORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 20, 2026

Spatial transcriptomics identifies the Pseudomonas aeruginosa major outer membrane protein OprF as a critical factor in blinding corneal infections

Serena Abbondante, Hao Zhu, Nicole M. Chumbler…·Mihaela G. Gadjeva

The paper identifies OprF as critical for Pseudomonas aeruginosa virulence in corneal infections by linking it to ExoT expression and ROS inhibition.

DOI 10.64898/2026.05.20.726515

bacteria (other)spatial transcriptomics

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MicrobiologyCell GenomicsPeer-reviewedMar 1, 2025

Spatial transcriptomics identifies novel Pseudomonas aeruginosa virulence factors

Hao Zhou, Oscar A. Negrón, Serena Abbondante…·Mihaela G. Gadjeva

This study uses spatial transcriptomics to identify novel Pseudomonas aeruginosa virulence factors and host-pathogen interactions in ocular infection.

6 citations

mousespatial transcriptomics

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Synthetic BiologyACS Chemical BiologyPeer-reviewedFeb 23, 2023

Rapid Single-Shot Synthesis of the 217 Amino Acid-Long N-Terminal Domain of Pyocin S2

Azin Saebi, Joseph S. Brown, Victoria M. Marando…·Bradley L. Pentelute

The paper synthesizes a 217 amino acid-long N-terminal domain of pyocin S2 using automated fast-flow peptide synthesis, achieving rapid production and selective uptake in Pseudomonas aeruginosa.

36 citations

bacteria (other)protein sequence

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