Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry
Jules Lavalou, Qiyan Mao, Stefan Harmansa, Stephen Kerridge, Annemarie Coffman Lellouch, Jean‐Marc Philippe, Stéphane Audebert, Luc Camoin, Thomas Lecuit
The paper shows that Toll-8 and Cirl GPCRs form an asymmetric complex to polarize Myosin-II, driving planar cell intercalations during Drosophila embryonic axis extension.
Developmental Cell · Apr 30, 2021Peer-reviewedDevelopmental Biology