Thomas Lecuit

The paper shows how stochastic dynamics and cytoskeletal regulation shape distinct neuronal morphologies in Drosophila mechanosensory neurons.

The paper shows that a mechanogen gradient controls contractility during Drosophila gastrulation by regulating actomyosin contractility through Fog signaling.

The paper shows how mechanical stress and basement membrane properties drive different epithelial cell shape transitions in Drosophila wing development.

The paper shows how mechanical coupling between Myosin-II activation and adhesion/de-adhesion drives a cell contractile wave during Drosophila tissue morphogenesis.

This study identifies a conserved role of serotonin signaling in regulating actomyosin contractility during morphogenesis across Drosophila and chicken embryos.

The paper shows that polarized flow in Drosophila embryos is driven by geometric coupling of apical actomyosin contractility to tissue curvature, independent of adhesion.

This study shows how differential growth anisotropy in the extracellular matrix drives mechanical deformation and morphogenesis in the Drosophila wing imaginal disc.

The paper shows that Toll-8 and Cirl GPCRs form an asymmetric complex to polarize Myosin-II, driving planar cell intercalations during Drosophila embryonic axis extension.

The paper investigates how deterministic and stochastic mechanisms shape dendritic branching in Drosophila neurons, finding that primary branches grow deterministically while secondary branches exhibit stochastic behavior influenced by geometric feedback.

The paper shows that the Frl/Fmnl formin nucleates a persistent actin network in Drosophila epithelial cells, which regulates tissue deformability during morphogenesis.

The paper identifies distinct RhoGEFs that regulate apical and junctional actomyosin contractility in Drosophila ectoderm through G protein signaling during epithelial morphogenesis.

The paper shows that morphogenetic waves in Drosophila endoderm are initiated by transcriptional activation and driven by mechanical feedback, not by continuous gene expression.

The paper shows that dissipation stabilizes cell shape changes during tissue morphogenesis by analyzing Myosin II activity in Drosophila embryos.