Luc Camoin

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

The atypical cadherin CELSR2 regulates distinct epithelial-mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

This study identifies CELSR2 as a regulator of epithelial-mesenchymal plasticity and oxidative phosphorylation in triple-negative breast cancer, showing its role in shaping tumor heterogeneity.

QUANTITATIVE PROTEOMIC REVEALS HEME OXYGENASE-1 LOCALIZATION TO CELL-SURFACE LIPID RAFTS AND ITS ASSOCIATION WITH FERROPORTIN IN IRON-LOADED MACROPHAGES

This study uses quantitative proteomics to identify iron-induced changes in macrophage lipid rafts, revealing Hmox1 and Fpn colocalization and their role in iron homeostasis.

Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream

The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.

Cardiolipin constrains lipid unsaturation during anaerobic adaptation in Escherichia coli

This study investigates how cardiolipin influences lipid unsaturation and membrane function during anaerobic adaptation in E. coli, revealing its role in optimizing membrane protein function.

A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections

The paper identifies new interactors of the SET1C complex through yeast two-hybrid screens, revealing its roles in chromatin regulation, RNA biogenesis, and nuclear transport.

Deciphering the dynamic proteome of multiciliated cells

This study generates a stable MCC line to profile proteome dynamics during differentiation, identifying CDK7 as a critical regulator in Xenopus and human systems.

UFMylation of MRE11 is essential for telomere length and hematopoietic stem cell survival

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry

The paper shows that Toll-8 and Cirl GPCRs form an asymmetric complex to polarize Myosin-II, driving planar cell intercalations during Drosophila embryonic axis extension.

Integrative proteomic and phosphoproteomic profiling of prostate cell lines

This study profiles the proteomes and phosphoproteomes of four prostate cell lines to identify differentially expressed proteins and phosphosites associated with resistance and cancer progression.