Jean‐Marc Philippe

Encoding neuronal shape in the stochastic dynamics of branching processes

The paper shows how stochastic dynamics and cytoskeletal regulation shape distinct neuronal morphologies in Drosophila mechanosensory neurons.

Spatial patterning of contractility by a mechanogen gradient underlies Drosophila gastrulation

The paper shows that a mechanogen gradient controls contractility during Drosophila gastrulation by regulating actomyosin contractility through Fog signaling.

Evolutionarily conserved role of serotonin signaling in regulating actomyosin contractility during morphogenesis

This study identifies a conserved role of serotonin signaling in regulating actomyosin contractility during morphogenesis across Drosophila and chicken embryos.

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry

The paper shows that Toll-8 and Cirl GPCRs form an asymmetric complex to polarize Myosin-II, driving planar cell intercalations during Drosophila embryonic axis extension.

Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability

The paper shows that the Frl/Fmnl formin nucleates a persistent actin network in Drosophila epithelial cells, which regulates tissue deformability during morphogenesis.

Distinct RhoGEFs activate apical and junctional actomyosin contractility under control of G proteins during epithelial morphogenesis

The paper identifies distinct RhoGEFs that regulate apical and junctional actomyosin contractility in Drosophila ectoderm through G protein signaling during epithelial morphogenesis.

Transcriptional induction and mechanical propagation of a morphogenetic wave

The paper shows that morphogenetic waves in Drosophila endoderm are initiated by transcriptional activation and driven by mechanical feedback, not by continuous gene expression.