Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis
Matthew T. Stier, Allison E. Sewell, Erin L. Mwizerwa, Chooi Ying Sim, Steve Tanner, Casey M. Nichols, Heather H. Durai, Erin Q. Jennings, Paul Lindau, Erin M. Wilfong, Sarah N. Obeidalla, Vern Eric Kerchberger, Dawn C. Newcomb, Julie A. Bastarache, Lorraine B. Ware, Jeffrey C. Rathmell
The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.
Nature Immunology · Jan 15, 2026Peer-reviewedImmunology