Steven J. Grzegorski

This paper uses a zebrafish model to identify genetic modifiers of thrombosis, finding a novel mutation in prothrombin and additional modifiers like factor X and plasminogen.

This study shows that disrupting the kringle 1 domain of prothrombin in zebrafish causes late-onset mortality due to impaired clot formation, revealing its role in thrombin biosynthesis and activation.

This study identifies polyketide synthase (pks1) mutations in zebrafish mutants that fail to develop otoliths, showing distinct processes for otolith nucleation and biomineralization independent of Oc90.