Catherine E. Richter

This paper uses a zebrafish model to identify genetic modifiers of thrombosis, finding a novel mutation in prothrombin and additional modifiers like factor X and plasminogen.

The paper shows that loss of FVIII in zebrafish reduces antithrombin deficiency but does not significantly cause bleeding, suggesting a unique hemostatic balance.

This study conducts a multi-ancestry GWAS for venous thromboembolism, identifies novel loci, and validates their function in zebrafish.

The paper studies zebrafish factor V mutants to determine minimal hemostasis requirements and evaluates human F5 variants for their residual function.