Author

Alexander P. Friedmann

Thrombosis and Atherosclerosis Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Colin A. KretziD· 2 shared Hasam MadaratiiD· 2 shared Jordan A. ShavitiD· 2 shared Paul Y. KimiD· 2 shared Steven J. Grzegorski· 2 shared Xinge YuiD· 2 shared Allison C. FergusoniD· 1 shared Andy H. VoiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Colin A. KretzORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis

Steven J. Grzegorski, Y Liu, Catherine E. Richter, Murat Yaman, Andy H. Vo, Xinge Yu, Anna R. Dahlgren, Hasam Madarati, Alexander P. Friedmann, Ida L. Surakka, Paul Y. Kim, Colin A. Kretz, Jordan A. Shavit

This paper uses a zebrafish model to identify genetic modifiers of thrombosis, finding a novel mutation in prothrombin and additional modifiers like factor X and plasminogen.

bioRxiv · May 13, 2026 · PreprintCell Biology

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

Steven J. Grzegorski, Zhilian Hu, Yang Liu, Xinge Yu, Allison C. Ferguson, Hasam Madarati, Alexander P. Friedmann, Deepak Reyon, Paul Y. Kim, Colin A. Kretz, J. Keith Joung, Jordan A. Shavit

This study shows that disrupting the kringle 1 domain of prothrombin in zebrafish causes late-onset mortality due to impaired clot formation, revealing its role in thrombin biosynthesis and activation.

Scientific Reports · Mar 4, 2020Peer-reviewedGenetics