Jordan A. Shavit

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis

This paper uses a zebrafish model to identify genetic modifiers of thrombosis, finding a novel mutation in prothrombin and additional modifiers like factor X and plasminogen.

Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism

This study identifies novel small molecules that prevent LPS-induced endotoxemia in zebrafish, showing that dabigatran protects through a thrombin-independent mechanism.

Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling

This study shows that rbm8a deficiency in zebrafish causes hematopoietic defects by impairing non-canonical Wnt/PCP signaling, leading to reduced thrombocytes and LPM anomalies.

FDA-approved drug repurposing in zebrafish identifies thyroid hormone and other compounds as potential antithrombotics

This study uses zebrafish to screen FDA-approved drugs for antithrombotic effects, identifying thyroid hormone and others as potential treatments for VTE subtypes.

Species-specific, multifaceted venom resistance in Monodelphis domestica reveals novel physiological behavior of von Willebrand Factor under flow.

This study investigates venom resistance in Monodelphis domestica, finding it resists venom-induced coagulation disruption and has unique von Willebrand Factor behavior under flow.

Identification of the role of SEL1L in platelet function through a multi-species genetic investigation

The paper identifies SEL1L's role in platelet function across species, showing it is necessary for platelet adhesion to injured sites.

Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

The paper shows that loss of FVIII in zebrafish reduces antithrombin deficiency but does not significantly cause bleeding, suggesting a unique hemostatic balance.

Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish

This study conducts a multi-ancestry GWAS for venous thromboembolism, identifies novel loci, and validates their function in zebrafish.

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

This study shows that disrupting the kringle 1 domain of prothrombin in zebrafish causes late-onset mortality due to impaired clot formation, revealing its role in thrombin biosynthesis and activation.

Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variants

The paper studies zebrafish factor V mutants to determine minimal hemostasis requirements and evaluates human F5 variants for their residual function.

Zebrafish Otolith Biomineralization Requires Polyketide Synthase

This study identifies polyketide synthase (pks1) mutations in zebrafish mutants that fail to develop otoliths, showing distinct processes for otolith nucleation and biomineralization independent of Oc90.

Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation

This study identifies 111 genetic loci and 163 risk variants associated with atrial fibrillation using a GWAS of over 1 million individuals.