Author

Sudeshna Das

University of California, IrvinePrimary ORCID profile (0000-0002-9486-6811 · 14 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Sudeshna DasiD14 papers · Harvard University

Biology Disciplines

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Neuroscience· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Vivek SwarupiD· 4 shared Zechuan ShiiD· 3 shared Elizabeth HeadiD· 2 shared Emily MiyoshiiD· 2 shared Justine A. SilvaiD· 2 shared Negin RahimzadehiD· 2 shared Nora EmersoniD· 2 shared Samuel MorabitoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Vivek SwarupORCID

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4 papers

Recent·Most cited

Metabolic reallocation in spinal cord oligodendrocytes drives chronic pain via neuronal β-amyloid production

Yannick Fotio, Saeed Al Masri, Zechuan Shi, Johnny Le, Sudeshna Das, Varvara I. Rubtsova, Alex Mabou Tagne, Cholsoon Jang, Vivek Swarup, Daniele Piomelli

This paper shows that spinal cord oligodendrocyte metabolic changes after injury lead to β-amyloid production and chronic pain.

Journal of Pain · Mar 1, 2026Peer-reviewedNeuroscience

Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease

Zechuan Shi, Sudeshna Das, Samuel Morabito, Jennifer T. Stocksdale, Emily Miyoshi, Shushrruth Sai Srinivasan, Nora Emerson, Arshi Shahin, Negin Rahimzadeh, Zhenkun Cao, Justine A. Silva, Andres Alonso Castaneda, Elizabeth Head, Leslie Michels Thompson, Vivek Swarup

This study uses single-nucleus multi-omics to identify shared and distinct regulatory pathways in Pick's and Alzheimer's disease, revealing disease-specific enhancers and TF binding patterns.

Science Advances · Nov 12, 2025Peer-reviewedNeuroscience

Dichotomous transcriptome divergence at the cell-type level between the Drosophila male and female germlines

Imtiyaz E. Hariyani, Sudeshna Das, Eli Le, Carmen Gamero-Castano, Tina Soroudi, Joshua Choi, Vivek Swarup, José M. Ranz

The paper compares gene expression divergence between male and female germlines in Drosophila species using single-nucleus RNA-seq, finding cell-type-specific patterns and X chromosome enrichment.

bioRxiv · Jul 4, 2025 · PreprintEvolutionary Biology

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience