Author

Caden M. Henningfield

University of California, IrvineORCID 0000-0002-9062-8672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Kim N. GreeniD· 2 shared Vivek SwarupiD· 2 shared Elizabeth HeadiD· 1 shared Emily MiyoshiiD· 1 shared Eric W. Doran· 1 shared Fairlie ReeseiD· 1 shared Grant R. MacGregoriD· 1 shared Ira T. LottiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Kim N. GreenORCID

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2 papers

Recent·Most cited

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia

Caden M. Henningfield, M. Ngo, Kaitlin M. Murray, Nellie E. Kwang, Kate Inman Tsourmas, Jonathan C. Neumann, Zachary A. Pashkutz, Shimako Kawauchi, Vivek Swarup, Thomas E. Lane, Grant R. MacGregor, Kim N. Green

The paper develops a mouse model to specifically target disease-associated microglia (DAMs) using an inducible Cre system and validates its specificity through spatial transcriptomic analysis.

Glia · Feb 23, 2025Peer-reviewedNeuroscience

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience