Zhenkun Cao

The paper constructs a single-nucleus transcriptomic atlas of Alzheimer's disease and identifies cell-type-specific molecular subtypes and therapeutic targets using a new framework.

The paper introduces SeqTag, a single-cell multiomics method, to analyze molecular asynchrony in regulatory layers and model cellular kinetics during aging.

The paper identifies age-related dysregulation of transcription networks in oligodendrocyte differentiation using single-nucleus RNA and ATAC sequencing in mice, with parallels in MS lesions.

This study uses single-nucleus multi-omics to identify shared and distinct regulatory pathways in Pick's and Alzheimer's disease, revealing disease-specific enhancers and TF binding patterns.

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.