Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics
Daiki X. Sato, Markos Michail Chatzigiannis, Hirotaka Shoji, Giovanni Sala, Satoko Hattori, Keizo Takao, Tatsuo Kinashi, Tatsuya Kishino, Sumiyo Morita, Izuho Hatada, Yo Shinoda, Kotaro Hattori, Takeshi Yagi, Akinobu Matsumoto, Hideo Egawa, , Tsuyoshi Miyakawa
The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.
bioRxiv · Jul 17, 2026 · PreprintNeuroscience