MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis
Sunehera Sarwat, Rosa Alén, Zhiyi Wu, Chuyue Zhang, Michal Paszek, MingMing Yang, Giada Ostinelli, Alina Mihalovits, Bell Baker, Timothy Wai, Guy A. Rutter, Tristan A. Rodríguez, Aida Martínez-Sánchez
This study identifies MTFP1 as critical for β-cell mitochondrial structure and function, essential for insulin secretion and glucose homeostasis, and shows its role as a downstream effector of miR-125b.
bioRxiv · Feb 3, 2026 · PreprintCell Biology