Giada Ostinelli

This study examines changes in adipose tissue fibrosis and ECM components in response to bariatric surgery and their association with weight loss and MASLD features.

This study identifies MTFP1 as critical for β-cell mitochondrial structure and function, essential for insulin secretion and glucose homeostasis, and shows its role as a downstream effector of miR-125b.

This study examines the impact of SNP rs28571848 on AKR1C3 expression and cardiometabolic health in bariatric surgery candidates with severe obesity.

This paper develops and validates an automated method using open-source software to measure adipocyte diameters in histological slides, showing strong correlation with manual measurements and associations with cardiometabolic markers.

This paper investigates sex-dependent effects of dorzagliatin and incretin on insulin secretion in a novel GCK-MODY mouse model, finding additive benefits in males but not females.