Pulsatile flow dynamics determine pulmonary arterial architecture
Stephen B. Spurgin, Lauren Thai, Tina C. Wan, Christopher P. Chaney, Mitzy A. Cowdin, Suren V. Reddy, Tarique Hussain, Munes Fares, M. Luisa Iruela-Arispe, Thomas J. Carroll, Andrew D. Spearman, Ondine B. Cleaver
The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.
bioRxiv · Jun 30, 2025 · PreprintPhysiology