Christopher P. Chaney

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

This study uses single-nucleus transcriptomics to analyze age-related changes in mouse kidney regions, revealing region-specific and cell-type-specific aging patterns in podocytes.

This study integrates spatial and single-nucleus transcriptomics to create a gene expression atlas of developing mouse kidneys, revealing heterogeneity in pericytes and introducing the KSTAT tool for analysis.

This study identifies nine endothelial cell types in the developing murine kidney using snucRNA-Seq and validates novel biomarkers through RNAScope.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This study identifies HGF as a key inducer of epithelial tubule anastomosis in vitro and in embryonic kidneys, revealing a proliferation-independent mechanism involving MAPK and MMPs.

This study identifies netrin-1 as a regulator of vascular patterning in kidney development, showing its role in arterial formation and mural cell differentiation through the Ntn1-Klf4 axis.

The paper characterizes the heterogeneity of the interstitium during kidney development and identifies distinct cell states and roles for beta-catenin in medullary interstitial cells.