Ondine B. Cleaver

This study identifies distinct roles for WWC2 and WWC3 in human endothelial cells, showing WWC3's dominance in Hippo signaling and WWC2's role in VEGF signaling, with both affecting EC proliferation and migration.

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

This paper develops an in vitro model of complex flow patterns using engineered geometries and computational fluid dynamics to study endothelial cell adaptation to hemodynamic forces.

This study integrates spatial and single-nucleus transcriptomics to create a gene expression atlas of developing mouse kidneys, revealing heterogeneity in pericytes and introducing the KSTAT tool for analysis.

This study identifies nine endothelial cell types in the developing murine kidney using snucRNA-Seq and validates novel biomarkers through RNAScope.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This paper shows that Lats1/2 are essential for vascular remodeling and response to shear stress in embryonic endothelial cells, leading to vascular defects and embryonic lethality.

This paper investigates the expression and localization of Hippo signaling components during early pancreatic development in mice, finding distinct patterns of YAP1 and TAZ expression in progenitor and endocrine cells.

This study investigates the spatiotemporal dynamics of primary and motile cilia during lung development, revealing distinct patterns in endothelial, epithelial, and mesenchymal cells.

This study identifies netrin-1 as a regulator of vascular patterning in kidney development, showing its role in arterial formation and mural cell differentiation through the Ntn1-Klf4 axis.

This study shows Rab11 is essential for pancreas development, lumen formation, and endocrine mass by regulating epithelial morphogenesis and vesicle trafficking.

This paper identifies Cyp26b1 as a gene critical for heart valve development in mice, showing its role in restricting cell proliferation and preventing defects like ventricular septal defects.

This study investigates the role of Cyp26b1 in lung development, finding that its loss disrupts distal epithelial differentiation and leads to neonatal death.