Stephen B. Spurgin

This paper develops an in vitro model of complex flow patterns using engineered geometries and computational fluid dynamics to study endothelial cell adaptation to hemodynamic forces.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This paper shows that Lats1/2 are essential for vascular remodeling and response to shear stress in embryonic endothelial cells, leading to vascular defects and embryonic lethality.

This study investigates the spatiotemporal dynamics of primary and motile cilia during lung development, revealing distinct patterns in endothelial, epithelial, and mesenchymal cells.