Thomas J. Carroll

Transient architecture of the embryonic pancreas determines endocrine mass

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS

This study uses single-nucleus transcriptomics to analyze age-related changes in mouse kidney regions, revealing region-specific and cell-type-specific aging patterns in podocytes.

Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population

The paper shows that defects in nephron progenitor cell differentiation lead to an expansion of Foxd1+ stromal progenitors in mouse models and identifies a conserved subcluster in human fetal kidneys.

Integration of spatial and single nucleus transcriptomics to map gene expression in the developing mouse kidney

This study integrates spatial and single-nucleus transcriptomics to create a gene expression atlas of developing mouse kidneys, revealing heterogeneity in pericytes and introducing the KSTAT tool for analysis.

Mitochondrial organization in the developing proximal tubule is controlled by LRRK2

This study shows that mitochondrial redistribution in developing proximal tubule cells depends on fluid flow and LRRK2 activity, which is regulated by shear stress.

Zonal endothelial cell heterogeneity underlies murine renal vascular development.

This study identifies nine endothelial cell types in the developing murine kidney using snucRNA-Seq and validates novel biomarkers through RNAScope.

Pulsatile flow dynamics determine pulmonary arterial architecture

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

This study identifies HGF as a key inducer of epithelial tubule anastomosis in vitro and in embryonic kidneys, revealing a proliferation-independent mechanism involving MAPK and MMPs.

Stromal netrin-1 coordinates renal arteriogenesis and mural cell differentiation

This study identifies netrin-1 as a regulator of vascular patterning in kidney development, showing its role in arterial formation and mural cell differentiation through the Ntn1-Klf4 axis.

Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids

This study shows that asynchronous mixing of kidney progenitor cells in organoids enhances nephrogenesis and functional features, but stromal overgrowth limits long-term study.

Proliferation control of kidney interstitial cells

This study shows that TGFβ/Smad signaling controls interstitial cell proliferation in the neonatal kidney by inhibiting Wnt/β-catenin signaling to prevent over-proliferation.

Characterization of interstitial heterogeneity in the developing kidney

The paper characterizes the heterogeneity of the interstitium during kidney development and identifies distinct cell states and roles for beta-catenin in medullary interstitial cells.

Molecular determinants of WNT9b responsiveness in nephron progenitor cells

The paper identifies Fzd5, Lrp6, and Rspon1 as critical components required for WNT9b responsiveness in nephron progenitor cells.