A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development
Susanne Bour, Yanina Dening, Melanie Balbach, Ina Poser, Inés Ramírez Álvarez, Helena den-Haan, Christoph Kluge, Ronald Naumann, Reinhard Oertel, Irene Alba‐Alejandre, Davide Accardi, Christian Georg Stief, Marianne Dieterich, Peter Falkai, Rainer A. Böckmann, , Francisco J. Pan-Montojo
This study shows that DJ-1 metabolites GA and DL can rescue fertility and mitochondrial dysfunction in multiple species, with GA having broader effects across models.
bioRxiv · Jan 16, 2021 · PreprintDevelopmental Biology