A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Fabian Munder, Matthew D. Johnson, Imogen Samuels, Laura C. McCaughey, Oleksii Zdorevskyi, Chunxiao Wang, Ashleigh Kropp, Lauren Zavan, Erin P. Price, Derek S. Sarovich, Swati Varshney, Christopher A. McDevitt, Hariprasad Venugopal, Vivek Sharma, Matthew Thomas Doyle, , Rhys Grinter
This study shows that L-type pyocins inhibit the BAM complex at the cell surface to kill Pseudomonas aeruginosa without entering the cell.
bioRxiv · Sep 18, 2025 · PreprintMicrobiology