Chunxiao Wang

This study identifies how diverse Llps inhibit the BAM complex by β-signal mimicry, revealing structural and functional mechanisms across Pseudomonas species.

This study uses AI to model RXFP1-relaxin interactions and designs potent mini-protein modulators that act as agonists or antagonists.

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

This study shows that L-type pyocins inhibit the BAM complex at the cell surface to kill Pseudomonas aeruginosa without entering the cell.

This study designs de novo proteins to inhibit E. coli's heme extraction from hemoglobin, demonstrating their effectiveness at low nanomolar concentrations.