Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice
H. Tye, S. A. Conos, T. M. Djajawi, N. Abdoulkader, I. Y. Kong, H. L. Kaummon, V. K. Narayana, M. Speir, T. A. Gottschalk, J. Emery, D. S. Simpson, C. Hall, A. J. Vince, S. Russo, R. Crawley, , K. Lawlor
This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.
bioRxiv · Mar 14, 2023Immunology