D. P. De Souza

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

This study shows that HDAC4 and HDAC5 inhibit cell death pathways and protect muscle integrity by reducing oxidative metabolism and promoting survival under lipotoxic stress.

Remodelling of carbon metabolism during sulfoglycolysis in Escherichia coli

This study identifies metabolic changes in Escherichia coli when grown on sulfoquinovose versus glucose, revealing increased storage carbohydrate synthesis and reduced TCA cycle flux.

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

Microbe-metabolite associations linked to the rebounding murine gut microbiome post-colonization with vancomycin resistant Enterococcus faecium

This study investigates how the gut microbiome changes in mice after colonization with vancomycin-resistant Enterococcus faecium, identifying metabolite associations linked to bacterial shifts.

Proteome analysis of human visceral and subcutaneous adipocytes identifies depot-specific heterogeneity at metabolic control points

The paper identifies depot-specific proteomic differences in human adipocytes from visceral, subcutaneous, and gluteal-femoral adipose tissue, revealing metabolic heterogeneity.

Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome

This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.