Author

T. A. Posey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

A. N. Parkhurst· 1 shared J. Jacob· 1 shared K. S. Carmon· 1 shared L. E. Francisco· 1 shared S. Subramanian· 1 shared Z. Liang· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

A. N. Parkhurst

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1 paper

Recent·Most cited

Loss of LGR5 through plasticity or gene ablation is associated with therapy resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

T. A. Posey, J. Jacob, A. N. Parkhurst, S. Subramanian, L. E. Francisco, Z. Liang, K. S. Carmon

This study shows that loss of LGR5 in colorectal cancer cells through plasticity or gene ablation activates MET-STAT3 signaling, leading to therapy resistance and suggesting new treatment strategies targeting plasticity.

bioRxiv · Mar 1, 2022 · PreprintCancer Biology