J. Jacob

Tube2FEM: a general-purpose highly-automated pipeline for flow related processes in (embedded) tubular objects

This paper introduces a highly-automated pipeline for generating simulation-ready meshes of tubular structures, enabling CFD simulations across various biomedical and industrial applications.

Flexible Cell Modeling Using Frequency Modulation

The paper introduces a Frequency Modulation model for real-time cell and tissue emulation on FPGA, capable of replicating detailed cell models and simulating cellular dysfunctions.

Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states

This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

This study develops and tests EREG-targeting ADCs showing efficacy in both RAS mutant and wildtype CRC, with high potency and safety in preclinical models.

On the ecology of Acinetobacter baumannii - jet stream rider and opportunist by nature

This study identifies white storks as a model system to explore the ecology of Acinetobacter baumannii, revealing its environmental reservoirs, seasonality, and genetic diversity across Europe.

Small in size but huge as reservoir -- insights into the virome of European white-toothed shrews

The paper identifies a diverse virome in European white-toothed shrews, including novel viral species related to WHO priority pathogens, and highlights their potential role in zoonotic spillover.

Functional effects of TBC1 domain containing kinase deletion in immortalized B cells and plasma cells

This study investigates the functional effects of TBCK deletion in B cells and plasma cells, finding reduced immunoglobulin secretion in knockout plasma cells.

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

This study maps the entire human kidney vasculature using hierarchical phase-contrast tomography, revealing structural differences in vascular architecture across kidney zones.

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer

This study develops an antibody-drug conjugate targeting GPR56 and shows it is effective against colorectal cancer models.

Loss of LGR5 through plasticity or gene ablation is associated with therapy resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

This study shows that loss of LGR5 in colorectal cancer cells through plasticity or gene ablation activates MET-STAT3 signaling, leading to therapy resistance and suggesting new treatment strategies targeting plasticity.

A multiscale X-ray phase-contrast tomography dataset of whole human left lung

The paper presents a high-resolution X-ray tomography dataset of a whole human left lung, capturing multiscale anatomical details from macroscopic to microscopic levels.

Phumdis-A Promising Alternative Energy Resource

This paper evaluates Phumdis from Loktak Lake as a potential alternative energy source, finding they have high calorific content and fuel properties comparable to other fuels.

Bacterioplankton diversity and pollution levels in the estuarine regions of Chaliyar and Anjarakkandi rivers, Kerala, India

The study compares bacterioplankton diversity and pollution levels between two estuarine regions, finding higher pollution and eutrophication in Anjarakkandi river.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.

96-Well Oxygen Control Using a 3D-Printed Device

This paper introduces a 96-well plate device that delivers 12 unique oxygen concentrations to enable high-throughput oxygen-controlled cell experiments.

RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model

This study shows that RELA mediates IL-1 repression of AR mRNA and activity in PCa cells, with stronger effects in castration-resistant sublines.