Author

L. E. Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Jacob· 2 shared K. S. Carmon· 2 shared S. Subramanian· 2 shared Z. Liang· 2 shared A. N. Parkhurst· 1 shared A. O. Brown· 1 shared B. E. Murray· 1 shared D. A. Garsin· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

J. Jacob

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer

J. Jacob, L. E. Francisco, T. Chatterjee, Z. Liang, S. Subramanian, Q. J. Liu, J. H. Rowe, K. S. Carmon

This study develops an antibody-drug conjugate targeting GPR56 and shows it is effective against colorectal cancer models.

bioRxiv · Aug 11, 2022Cancer Biology

Loss of LGR5 through plasticity or gene ablation is associated with therapy resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

T. A. Posey, J. Jacob, A. N. Parkhurst, S. Subramanian, L. E. Francisco, Z. Liang, K. S. Carmon

This study shows that loss of LGR5 in colorectal cancer cells through plasticity or gene ablation activates MET-STAT3 signaling, leading to therapy resistance and suggesting new treatment strategies targeting plasticity.

bioRxiv · Mar 1, 2022 · PreprintCancer Biology

Cardiac Microlesions Form During Severe Bacteremic Enterococcus faecalis Infection

A. O. Brown, K. V. Singh, M. R. Cruz, K. G. Kaval, L. E. Francisco, B. E. Murray, D. A. Garsin

The paper shows that severe E. faecalis bacteremia in mice causes cardiac microlesions, identifies DsbA as a virulence factor involved, and links it to immune response modulation.

bioRxiv · Jan 14, 2020Microbiology