T. Bishop

CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.