Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
M. O. Dobrica, C. S. Varghese, J. M. Harris, J. Ferguson, A. Magri, R. Arnold, C. Varnai, J. L. Parish, J. A. McKeating
This study shows that CTCF regulates HBV cccDNA chromatin topology and nucleosomal positioning, affecting viral transcription.
bioRxiv · Sep 6, 2023Microbiology
H. Borrmann, G. Ulkar, A. E. Kliszczak, D. Ismed, M. Schilling, A. Magri, J. M. Harris, P. Balfe, S. Vasudevan, P. Borrow, X. Zhuang, J. A. McKeating
This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.
bioRxiv · Nov 30, 2022 · PreprintMicrobiology
P. A. Wing, M. Prange-Barczynska, A. Cross, S. Crotta, C. Orbegozo Rubio, X. Cheng, J. M. Harris, X. Zhuang, R. L. Johnson, K. A. Ryan, Y. Hall, M. W. Carroll, F. Issa, P. Balfe, A. Wack, , J. A. McKeating
This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.
bioRxiv · Mar 15, 2022Microbiology
X. Zhuang, S. Tsukuda, F. Wrensch, P. A. Wing, M. Schilling, J. M. Harris, H. Borrmann, S. B. Morgan, J. L. Cane, L. Mailly, N. Thakur, C. Conceicao, H. Sanghani, L. Heydmann, C. Bach, , J. A. McKeating
This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.
bioRxiv · Mar 20, 2021Microbiology
V. D'Arienzo, J. Ferguson, G. Giraud, F. Chapus, J. M. Harris, P. A. Wing, A. Claydon, S. Begum, X. Zhuang, P. Balfe, B. Testoni, J. A. McKeating, J. L. Parish
This study identifies CTCF as a repressor of HBV transcription by binding to Enhancer I and reducing pre-genomic RNA levels.
Cellular Microbiology · Oct 16, 2020Peer-reviewedMicrobiology
P. J. Liu, J. M. Harris, E. Marchi, V. D'Arienzo, T. Michler, P. A. Wing, A. Magri, A. Otega-Prieto, M. Van de Klundert, J. Wettengel, D. Durantel, M. Dorner, P. Klenerman, U. Protzer, S. Giotis, J. A. McKeating
The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.
bioRxiv · Mar 27, 2020Microbiology