Author

T. Bracht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

B. Sitek· 4 shared M. Trilling· 3 shared V. T. K. Le-Trilling· 3 shared M. Eisenacher· 2 shared A. Belter· 1 shared A. Dixit· 1 shared A. Graziadei· 1 shared A. Krawczyk· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

B. Sitek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

F. Maassen, V. T. K. Le-Trilling, L. Betke, T. Bracht, C. Schuler, M. Bayer, A. Belter, T. Becker, B. Katschinski, L. Frappier, B. Sitek, K. Fleischhauer, M. Trilling

This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.

bioRxiv · Oct 17, 2023 · PreprintImmunology

Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

V. T. K. Le-Trilling, S. Banchenko, D. Paydar, P. M. Leipe, L. Binting, S. Lauer, A. Graziadei, C. Gotthold, J. Burger, T. Bracht, B. Sitek, R. J. Lebbink, A. Malyshkina, T. Mielke, J. Rappsilber, , D. Schwefel

This study identifies E27 as a viral protein that targets STAT2 for degradation via CRL4 ubiquitin ligases, revealing its structural mechanism of interferon antagonism.

bioRxiv · May 5, 2022Biochemistry

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

J. Schuhenn, T. L. Meister, D. Todt, T. Bracht, K. Schork, J.-N. Billaud, C. Elsner, N. Heinen, Z. Karakoese, S. Haid, S. Kumar, L. Brunotte, M. Eisenacher, J. Chen, Z. Yuan, , S. Pfaender

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

bioRxiv · May 20, 2021 · PreprintCell Biology

Relocation of macrophages maintains the barrier function of the urothelium and protects against persistent infection

J. Bottek, C. Soun, J. K. Volke, A. Dixit, S. Thiebes, A.-L. Beerlage, M. Horstmann, A. Urbanek, J. Uszkoreit, M. Eisenacher, T. Bracht, B. Sitek, F. Hoffmann, N. Vijitha, F. von Eggeling, D. R. Engel

The paper shows that macrophage relocation into the urothelium, driven by IL-6 and CX3CL1, helps maintain barrier function and prevent recurrent urinary tract infections.

bioRxiv · Jun 6, 2019 · PreprintImmunology