Author

D. R. Engel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Soun· 2 shared D. Siemes· 2 shared P. Spangenberg· 2 shared A. Bazarna· 1 shared A. Dixit· 1 shared A. Paschen· 1 shared A. Urbanek· 1 shared A. W. Chan· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

C. Soun

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice

D. Geist, G. S. Hönes, S. C. Grund, J. Pape, D. Siemes, P. Spangenberg, E. Tolstik, S. Dörr, N. Spielmann, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, J. Mittag, D. R. Engel, D. Führer, , L. C. Moeller

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

bioRxiv · Nov 24, 2023Physiology

Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis

L. Borgards, B. Siebels, H. Voss, C. Krisp, J. Schmitz, L. Schwarz, D. Siemes, P. Spangenberg, J. H. Braesen, S. von Vietinghoff, H. Schluter, F. Wagenlehner, D. R. Engel, O. Shevchuk

This study identifies proteomic adaptations in human pyelonephritis, revealing elevated antimicrobial peptides and their potential protective role against systemic inflammation.

bioRxiv · Sep 14, 2023 · PreprintImmunology

Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

P. F. Cheung, J. Yang, K. Krengel, K. Althoff, C. Yip, E. H. Siu, L. W. Ng, K. S. Lang, L. Cham, D. R. Engel, C. Soun, I. Cima, B. Scheffler, J. K. Striefler, M. Sinn, , J. T. Siveke

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology

Relocation of macrophages maintains the barrier function of the urothelium and protects against persistent infection

J. Bottek, C. Soun, J. K. Volke, A. Dixit, S. Thiebes, A.-L. Beerlage, M. Horstmann, A. Urbanek, J. Uszkoreit, M. Eisenacher, T. Bracht, B. Sitek, F. Hoffmann, N. Vijitha, F. von Eggeling, D. R. Engel

The paper shows that macrophage relocation into the urothelium, driven by IL-6 and CX3CL1, helps maintain barrier function and prevent recurrent urinary tract infections.

bioRxiv · Jun 6, 2019 · PreprintImmunology