Author

R. J. Lebbink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

E. J. Wiertz· 2 shared E. Wiertz· 2 shared I. Drexler· 2 shared J. M. Beekman· 2 shared M. Nijhuis· 2 shared P. Praest· 2 shared W. Nijenhuis· 2 shared A. Akhmanova· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

E. J. Wiertz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

T. Cremer, H. Hoelen, M. L. van de Weijer, G. Janssen, A. I. Costa, P. van Veelen, R. J. Lebbink, E. Wiertz

This study identifies UBE2G2 as a key enzyme in the ERAD-mediated degradation of proinsulin, leading to the presentation of a proinsulin B-chain autoantigen in T1D.

PLOS ONE · May 24, 2024Peer-reviewedCell Biology

The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression

S. Zheng, H. de Buhr, P. Praest, A. Evers, I. Brak Boer, M. van Grinsven, Y. Longo, L. de Vries, W. Nijenhuis, L. C. Kapitein, J. M. Beekman, M. Nijhuis, I. Drexler, E. J. Wiertz, R. J. Lebbink

This study identifies SARS-CoV-2 ORF7a as a viral factor that downregulates MHC class I surface expression, impairing antigen presentation and immune surveillance.

bioRxiv · May 29, 2022 · PreprintMicrobiology

Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

V. T. K. Le-Trilling, S. Banchenko, D. Paydar, P. M. Leipe, L. Binting, S. Lauer, A. Graziadei, C. Gotthold, J. Burger, T. Bracht, B. Sitek, R. J. Lebbink, A. Malyshkina, T. Mielke, J. Rappsilber, , D. Schwefel

This study identifies E27 as a viral protein that targets STAT2 for degradation via CRL4 ubiquitin ligases, revealing its structural mechanism of interferon antagonism.

bioRxiv · May 5, 2022Biochemistry

Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells

W. Nijenhuis, H. G. J. Damstra, E. J. van Grinsven, M. K. Iwanski, P. Praest, Z. E. Soltani, M. M. P. van Grinsven, J. E. Brunsveld, T. M. De Kort, L. W. Rodenburg, D. C. M. de Jong, H. M. Raeven, S. Spelier, G. D. Amatngalim, A. Akhmanova, , L. C. M. Kapitein

This study uses advanced microscopy to show how SARS-CoV-2 changes the structure of human airway cells at the subcellular level.

bioRxiv · Aug 5, 2021 · PreprintCell Biology

Inhibitory CD200-receptor signaling is rewired by type I interferon

M. van der Vlist, M. I. Pascoal Ramos, L. L. van den Hoogen, S. Hiddingh, L. Timmerman, T. A. P. de Hond, E. D. Kaan, M. van der Kroef, R. J. Lebbink, F. M. A. Peters, W. Khoury-Hanold, R. Fritsch-Stork, T. Radstake, L. Meyaard

This study shows that type I interferon alters CD200R signaling by promoting RasGAP cleavage, converting CD200R from an inhibitor to a potentiator of IFNG mRNA production in SLE patients.

bioRxiv · Feb 6, 2020Immunology

Genetic editing of SEC61, SEC62, and SEC63 abrogates human cytomegalovirus US2 expression in a signal peptide-dependent manner

A. B. Schuren, I. G. J. Boer, E. Bouma, R. J. Lebbink, E. Wiertz

The paper shows that genetic disruption of SEC61, SEC62, and SEC63 affects human cytomegalovirus US2 expression, specifically dependent on its signal peptide.

bioRxiv · May 29, 2019 · PreprintCell Biology

A genome-wide haploid genetic screen for essential factors in vaccinia virus infection identifies TMED10 as regulator of macropinocytosis

R. D. Luteijn, F. R. van Diemen, V. A. Blomen, I. G. Boer, S. Manikam Sadasivam, T. van Kuppevelt, I. Drexler, T. R. Brummelkamp, R. J. Lebbink, E. J. Wiertz

bioRxiv · Dec 11, 2018 · PreprintMicrobiology