Author

T. Brignoli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

R. C. Massey· 6 shared M. Recker· 3 shared S. Duggan· 3 shared D. Altwiley· 2 shared E. J. A. Douglas· 2 shared E. O'Brien· 2 shared A. A. Alnahari· 1 shared A. M. Edwards· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersMicrobiology

R. C. Massey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein through competitive interference.

D. Bonini, S. Duggan, A. A. Alnahari, T. Brignoli, H. Strahl, R. C. Massey

This study shows that MspA regulates lipoteichoic acid levels in S. aureus by interfering with LtaA-LtaS interactions, affecting cell size and pathogenicity.

bioRxiv · May 9, 2023 · PreprintMicrobiology

Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia

E. J. A. Douglas, N. Palk, T. Brignoli, D. Altwiley, M. Boura, M. Laabei, M. Recker, G. C. Cheung, R. Liu, R. C. Hseih, M. Otto, E. O'Brien, R. M. McLoughlin, R. C. Massey

This study identifies TcaA as a key regulator of cell wall remodeling in Staphylococcus aureus during bacteraemia, enhancing virulence by altering wall teichoic acids and peptidoglycan crosslinking.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Wall teichoic acids facilitate the release of toxins from the surface of Staphylococcus aureus.

T. Brignoli, E. J. Douglas, S. Duggan, O. G. Fagunloye, R. P. Adhikari, J. Aman, R. C. Massey

This study identifies wall teichoic acids (WTA) as essential for the release of cytolytic toxins from Staphylococcus aureus by altering the electrostatic charge of the cell envelope.

bioRxiv · Jan 31, 2022Microbiology

Self-sensitisation of Staphylococcus aureus to the antimicrobial factors found in human blood.

E. Douglas, T. Brignoli, M. Recker, E. O'Brien, R. McLoughlin, R. C. Massey

This study identifies genetic factors in Staphylococcus aureus that influence serum survival, revealing how bacterial responses to blood factors affect their transition from commensal to invasive states.

bioRxiv · Jul 19, 2021 · PreprintMicrobiology

The MpsB protein contributes to both the toxicity and immune evasion capacity of Staphylococcus aureus.

E. J. A. Douglas, S. Duggan, T. Brignoli, R. C. Massey

This study identifies mpsB as a gene contributing to Staphylococcus aureus toxicity and immune evasion, linking it to disease severity and mortality.

bioRxiv · Jun 30, 2021Microbiology

A Functional Menadione Biosynthesis Pathway is Required for Capsule Production by Staphylococcus aureus.

D. Altwiley, T. Brignoli, A. M. Edwards, M. Recker, J. C. Lee, R. C. Massey

This study identifies menD as a regulator of capsule production in S. aureus through GWAS and functional validation, showing its role in gentamicin resistance without major growth defects.

bioRxiv · Jun 2, 2021Microbiology