Author

M. Laabei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

R. C. Massey· 3 shared A. Macpherson· 2 shared E. O'Brien· 2 shared M. Otto· 2 shared M. Recker· 2 shared A. Alnahari· 1 shared A. D. G. Lawson· 1 shared A. Lawson· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

R. C. Massey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia

E. J. A. Douglas, N. Palk, T. Brignoli, D. Altwiley, M. Boura, M. Laabei, M. Recker, G. C. Cheung, R. Liu, R. C. Hseih, M. Otto, E. O'Brien, R. M. McLoughlin, R. C. Massey

This study identifies TcaA as a key regulator of cell wall remodeling in Staphylococcus aureus during bacteraemia, enhancing virulence by altering wall teichoic acids and peptidoglycan crosslinking.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Significant Variability exists in the Toxicity of Global Methicillin-resistant Staphylococcus aureus Lineages.

M. Laabei, S. Peacock, B. Blane, S. L. Baines, T. P. Stinear, B. Howden, R. C. Massey

The paper assesses toxicity variability among global MRSA lineages and identifies Agr mutations linked to reduced toxicity, highlighting the role of undefined genes in toxin regulation.

bioRxiv · Jul 16, 2021Microbiology

The chemical synthesis of knob domain antibody fragments

A. Macpherson, J. R. Birtley, R. J. Broadbridge, K. Brady, Y. Tang, C. Joyce, K. Saunders, G. Bogle, J. Horton, S. Kelm, R. D. Taylor, R. J. Franklin, M. D. Selby, M. Laabei, T. Wonfor, , A. D. G. Lawson

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

bioRxiv · Jun 16, 2021 · PreprintBiochemistry

The allosteric modulation of Complement C5 by knob domain peptides

A. Macpherson, M. Laabei, Z. Ahdash, M. A. Graewert, J. Birtley, S. Schulze, S. Crennell, S. Robinson, B. Holmes, V. Oleinikovas, P. H. Nilsson, J. Snowden, V. Ellis, T. E. Mollnes, C. M. Deane, , J. van den Elsen

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

bioRxiv · Oct 24, 2020Immunology

A small membrane protein critical to both the offensive and defensive capabilities of Staphylococcus aureus.

R. C. Massey, S. Duggan, M. Laabei, A. Alnahari, E. O'Brien, K. Lacey, L. Bacon, K. Heesom, C.-L. Fu, M. Otto, E. Skaar, R. McLoughlin

This study identifies and characterizes MasA, a small membrane protein in S. aureus that disrupts toxin production and immune resistance when inactivated, impairing infection in multiple models.

bioRxiv · Oct 3, 2019 · PreprintMicrobiology

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

M. Yokoyama, M. Laabei, E. Stevens, S. Bayliss, N. Ooi, A. O'Neill, E. Murray, P. Williams, A. Lubben, S. Reeksting, G. Meric, B. Pascoe, S. Sheppard, M. Recker, L. Hurst, R. Massey

The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.

bioRxiv · Dec 9, 2017Microbiology