Allosteric control of Ubp6 and the proteasome via a bidirectional switch
K. Y. S. Hung, S. Klumpe, M. R. Eisele, S. Elsasser, G. Tian, S. Sun, J. A. Moroco, T. C. Cheng, T. Joshi, T. Seibel, D. Van Dalen, X.-H. Feng, Y. Lu, H. Ovaa, J. R. Engen, , D. Finley
This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.
bioRxiv · Jul 16, 2021Biochemistry