Author

J. A. Moroco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2

Frequent Co-Authors

J. R. Engen· 2 shared M. F. Mesleh· 2 shared A. G. Reidenbach· 1 shared A. I. Chan· 1 shared A. Ianari· 1 shared A. J. Campbell· 1 shared A. J. Leed· 1 shared A. Skepner· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

J. R. Engen

Author profile →

4 papers

Recent·Most cited

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

K. Y. S. Hung, S. Klumpe, M. R. Eisele, S. Elsasser, G. Tian, S. Sun, J. A. Moroco, T. C. Cheng, T. Joshi, T. Seibel, D. Van Dalen, X.-H. Feng, Y. Lu, H. Ovaa, J. R. Engen, , D. Finley

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

bioRxiv · Jul 16, 2021Biochemistry

Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction

D. C. McKinney, B. J. McMillan, M. Ranaghan, J. A. Moroco, M. Brousseau, Z. Mullin-Bernstein, M. O'Keefe, P. McCarren, M. F. Mesleh, K. M. Mulvaney, R. Singh, B. Bajrami, A. Skepner, D. E. Timm, D. Porter, , A. Ianari

The paper identifies a first-in-class inhibitor, BRD0639, that targets the PRMT5-PBM interaction, disrupting SAP binding and reducing substrate methylation in cancer cells.

bioRxiv · Feb 3, 2021 · PreprintCancer Biology

Multimodal small-molecule screening for human prion protein binders

A. G. Reidenbach, M. F. Mesleh, D. Casalena, S. M. Vallabh, J. L. Dahlin, A. J. Leed, A. I. Chan, D. L. Usanov, J. B. Yehl, C. T. Lemke, A. J. Campbell, R. N. Shah, O. K. Shrestha, J. R. Sacher, V. L. Rangel, , E. V. Minikel

This study screens for small-molecule binders of the human prion protein using multiple methods but finds only a weak binder with no therapeutic potential.

bioRxiv · Jun 18, 2020Biochemistry

Mitochondrial ClpX activates an essential metabolic enzyme through partial unfolding

J. R. Kardon, J. A. Moroco, J. R. Engen, T. A. Baker

The paper investigates how mitochondrial ClpX partially unfolds ALAS to activate it by gating cofactor access.

bioRxiv · May 21, 2018Biochemistry