Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease
R. Yamin, K. S. Kao, M. R. MacDonald, T. Cantaert, C. M. Rice, J. V. Ravetch, S. Bournazos
This study shows that anti-DENV IgG antibodies drive dengue pathogenesis via FcγRIIIa on splenic macrophages, leading to inflammation and mortality.
bioRxiv · Nov 2, 2022 · PreprintImmunology