M. R. MacDonald

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

This study shows that anti-DENV IgG antibodies drive dengue pathogenesis via FcγRIIIa on splenic macrophages, leading to inflammation and mortality.

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

A histone-like motif in yellow fever virus contributes to viral replication

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

Dengue virus hijacks a noncanonical oxidoreductase function of a cellular oligosaccharyltransferase complex

This study identifies the STT3B-containing oligosaccharyltransferase complex as essential for dengue virus infection, revealing its oxidoreductase activity is required for viral propagation.