Nasal delivery of single-domain antibodies improve symptoms of SARS-CoV-2 infection in an animal model
K. Haga, R. Takai-Todaka, Y. Matsumura, T. Takano, T. Tojo, A. Nagami, Y. Ishida, H. Masaki, M. Tsuchiya, T. Ebisudani, S. Sugimoto, T. Sato, H. Yasuda, K. Fukunaga, A. Sawada, , K. Katayama
This paper shows nasal delivery of a camelid single-domain antibody reduces SARS-CoV-2 titers in hamsters without weight loss or cytokine induction.
bioRxiv · Apr 9, 2021Microbiology