M. Tsuchiya

Organelle-selective click labeling coupled with flow cytometry allows high-throughput CRISPR screening of genes involved in phosphatidylcholine metabolism

This paper introduces O-ClickFC, a method combining organelle-selective click labeling and flow cytometry for CRISPR screening of genes involved in phosphatidylcholine metabolism, identifying both known and novel genes.

Evidence that conserved essential genes are enriched for pro-longevity factors

The paper shows that overexpressing conserved essential genes in yeast increases replicative lifespan more than deleting them, suggesting essential genes are important for longevity.

A Unified Genomic Mechanism of Cell-Fate Change

The paper proposes a genomic mechanism explaining cell-fate change through critical points and attractor dynamics in genome expression.

Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment

Nasal delivery of single-domain antibodies improve symptoms of SARS-CoV-2 infection in an animal model

This paper shows nasal delivery of a camelid single-domain antibody reduces SARS-CoV-2 titers in hamsters without weight loss or cytokine induction.

The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration

This study shows that PIEZO1, a mechanosensitive ion channel, promotes satellite cell function and skeletal muscle regeneration by mediating calcium influx and RhoA-mediated actomyosin formation.

Massive occurrence of benthic plastic debris at the abyssal seafloor beneath the Kuroshio Extension, the North West Pacific

The paper quantifies plastic debris on the abyssal seafloor beneath the Kuroshio Extension, finding high densities of single-use plastics, indicating the Northwest Pacific deep-sea basin is a major plastic reservoir.

Cell-Fate Determination from Embryo to Cancer Development: Genomic Mechanism Elucidated

This paper examines the genomic mechanism determining cell-fate changes from embryo to cancer development using self-organized criticality as a framework.