T. Takano

Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogrens syndrome

This study identifies dysregulated Ca2+ signaling and mitochondrial dysfunction in a mouse model of early Sjogrens syndrome, leading to reduced fluid secretion.

Unraveling the Role of Urea Hydrolysis in Salt Stress Response during Seed Germination and Seedling Growth in Arabidopsis thaliana

This study shows that salt stress increases urea hydrolysis in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, challenging the traditional view of ammonium toxicity as the main cause.

The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome.

The paper identifies an extrafollicular B cell response as a key feature of active childhood idiopathic nephrotic syndrome using single-cell RNA-sequencing and flow cytometry.

Feline Coronavirus Infection of Domestic Cats Causes Development of Cross-Reactive Antibodies to SARS-CoV-2 Receptor Binding Domain

This study shows that feline coronavirus-infected cats develop cross-reactive antibodies to SARS-CoV-2 RBD, despite low sequence similarity, suggesting potential for a pan-CoV vaccine.

Two doses of mRNA vaccine elicit cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant

The paper shows that two doses of mRNA vaccine generate cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant, which are retained and contribute to enhanced antibody responses after a third dose.

Nasal delivery of single-domain antibodies improve symptoms of SARS-CoV-2 infection in an animal model

This paper shows nasal delivery of a camelid single-domain antibody reduces SARS-CoV-2 titers in hamsters without weight loss or cytokine induction.

The characteristics of intracellular Ca2+ signals in vivo necessitate a new model for salivary fluid secretion

The study observes localized Ca2+ signals in live mice that contradict previous in vitro models of salivary secretion and proposes a new mathematical model to explain the mechanism.

Macroscopic digestive anatomy of ring-tailed lemurs (Lemur catta), including a comparison of frozen and formalin-stored specimens

This study quantifies macroscopic digestive anatomy in ring-tailed lemurs across ontogeny, comparing frozen and formalin-stored specimens and finding no significant storage method impact on measurements.

Subspecies and sexual craniofacial size and shape variations in Japanese macaques (Macaca fuscata)

This study examines craniofacial size and shape variations in Japanese macaques, finding differences between subspecies and sexes, but no strong link between size and subspeciation.

Repeated inversions at the pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The paper identifies pannier as a key regulatory gene for color pattern variation in ladybird beetles and shows that inversions and cis-regulatory changes at this gene drive intraspecific diversity.

Can the location of a trophectoderm biopsy contribute to human blastocyst development ?

This study investigates how the location of a trophectoderm biopsy in human blastocysts affects their development, finding that biopsies near the inner cell mass improve blastocoel development.