Author

T. Enzlein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Hopf· 4 shared L. Chavez-Gutierrez· 2 shared S. Lismont· 2 shared S. Schmidt· 2 shared A. Becker· 1 shared A. Geisel· 1 shared B. C. Froehlich· 1 shared B. Ozcan· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

C. Hopf

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Label-free Assessment of Complement-Dependent Cytotoxicity of Therapeutic Antibodies via a Whole-Cell MALDI Mass Spectrometry Bioassay

S. Schmidt, A. Geisel, T. Enzlein, B. C. Froehlich, L. Pritchett, M. Verneret, C. Graf, C. Hopf

This study develops a label-free MALDI-TOF mass spectrometry bioassay to assess complement-dependent cytotoxicity of Rituximab, identifying metabolite markers and demonstrating robust concentration-response characteristics.

bioRxiv · May 3, 2024Biochemistry

Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy

L. Gruber, S. Schmidt, T. Enzlein, H. G. Vo, J. L. Cairns, Y. Ucal, F. Keller, D. Abu Sammour, R. Rudolf, M. Eckhardt, S. A. Iakab, L. Bindila, C. Hopf

This paper introduces a method combining quantum cascade laser infrared imaging with mass spectrometry to improve molecular identification in spatial omics, achieving high-resolution lipidomics profiling.

bioRxiv · Dec 14, 2023Biochemistry

APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release

M. Koch, T. Enzlein, S.-Y. Chen, D. Petit, S. Lismont, M. Zacharias, C. Hopf, L. Chavez-Gutierrez

The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.

bioRxiv · Sep 13, 2023 · PreprintBiochemistry

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

K. M. Zoltowska, U. Das, S. Lismont, T. Enzlein, M. Maesako, M. C. Houser, D. Gomes Moreira, M. L. Franco, B. Ozcan, D. Karachentsev, A. Becker, C. Hopf, M. Vilar, O. Berezovska, W. Mobley, L. Chavez-Gutierrez

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

bioRxiv · Aug 2, 2023Biochemistry