Author

T. F. Custodio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Löw· 2 shared K. Remans· 2 shared A. Gruzinov· 1 shared B. M. Hällberg· 1 shared B. Murrell· 1 shared B. P. Pedersen· 1 shared C. Jeffries· 1 shared D. I. Svergun· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

C. Löw

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Deamidation drives molecular aging of the SARS-CoV-2 spike receptor-binding motif

R. Lorenzo, L. A. Defelipe, L. Aliperti, S. Niebling, T. F. Custodio, C. Löw, J. J. Schwarz, K. Remans, P. O. Craig, L. H. Otero, S. Klinke, M. Garcia-Alai, I. E. Sanchez, L. G. Alonso

This study identifies deamidation hotspots in the SARS-CoV-2 spike receptor-binding motif, showing how this post-translational modification affects viral infectivity and immune response over time.

bioRxiv · May 20, 2021Biochemistry

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

T. F. Custodio, H. Das, D. J. Sheward, L. Hanke, S. Pazicky, J. Pieprzyk, M. Sorgenfrei, M. Schroer, A. Gruzinov, C. Jeffries, M. Graewert, D. I. Svergun, N. Dobrev, K. Remans, M. Seeger, , C. Löw

This study isolates and characterizes synthetic nanobodies that neutralize SARS-CoV-2, identifying Sb23 with high affinity and neutralization activity.

bioRxiv · Jun 23, 2020Biophysics

Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in Sugar Porter family

T. F. Custodio, P. A. Paulsen, B. P. Pedersen, K. M. Frain

The paper compares the structure of GLUT1 and GLUT3 to explain differences in glucose affinity and identifies structural motifs that regulate transport in the Sugar Porter family.

bioRxiv · Feb 24, 2020 · PreprintBiochemistry