Author

T. G. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Organism:plant (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

E. Diez Benavente· 2 shared S. Campino· 2 shared A. A. van Belkum· 1 shared A. Coello Pelegrin· 1 shared A. Patel· 1 shared C. Akkale· 1 shared C. J. Sutherland· 1 shared D. A. Baker· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

E. Diez Benavente

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Author profile →

5 papers

Recent·Most cited

A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

R. C. Eccleston, E. Manko, S. Campino, T. G. Clark, N. Furnham

The paper predicts evolutionary trajectories of drug resistance mutations using a computational model parameterized by binding affinity, showing agreement with experimental and isolate data.

bioRxiv · Jan 25, 2022Evolutionary Biology

Tetrahymena thermophila Granule Lattice Protein 3 Improves Solubility of Sexual Stage Malaria Antigens Expressed in Escherichia coli

C. Akkale, D. M. Cassidy-Hanley, T. G. Clark

This study compares the solubility-enhancing effects of Grl3p and Grl1p with MBP on malaria antigens Pfs25 and Pfs48/45 expressed in E. coli, finding Grl3p improves solubility of Pfs48/45 more than others.

bioRxiv · Jun 29, 2021Bioengineering

Ribosome profiling in Mycobacterium tuberculosis reveals robust leaderless translation

E. B. Sawyer, J. E. Phelan, T. G. Clark, T. Cortes

This study uses ribosome profiling to show that Mycobacterium tuberculosis uses leaderless translation under nutrient starvation, suggesting distinct translational mechanisms.

bioRxiv · Apr 22, 2020Microbiology

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: An inter-laboratory study

R. M. Doyle, D. M. O'Sullivan, S. D. Aller, S. Bruchmann, T. G. Clark, A. Coello Pelegrin, M. Cormican, E. Diez Benavente, M. J. Ellington, E. McGrath, Y. Motro, T. Phuong Thuy Nguyen, J. Phelan, L. P. Shaw, R. A. Stabler, , K. A. Harris

This study evaluates the reproducibility of antimicrobial resistance predictions from whole-genome sequencing data across different laboratories and identifies factors contributing to discordant results.

Microbial Genomics · Feb 1, 2020Peer-reviewedMicrobiology

Rapid and iterative genome editing in the zoonotic malaria parasite Plasmodium knowlesi: New tools for P. vivax research

F. Mohring, M. N. Hart, T. A. Rawlinson, R. Henrici, J. A. Charleston, E. Diez Benavente, A. Patel, J. Hall, N. Almond, S. Campino, T. G. Clark, C. J. Sutherland, D. A. Baker, S. J. Draper, R. W. Moon

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

bioRxiv · Mar 28, 2019Microbiology