S. J. Draper

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

Evaluation of Precision of the Plasmodium knowlesi Growth Inhibition Assay for Plasmodium vivax Duffy-Binding Protein-based Malaria Vaccine Development

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Naturally acquired and Vaccine-induced Human Monoclonal Antibodies to Plasmodium vivax Duffy Binding Protein Inhibit Invasion of Plasmodium knowlesi (PvDBPOR) Transgenic Parasites

This paper evaluates the invasion inhibition of Plasmodium knowlesi transgenic parasites expressing PvDBP by naturally acquired and vaccine-induced human monoclonal antibodies, finding additive and antagonistic effects in combinations.

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

Low adenovirus vaccine doses administered to skin using microneedle patches induce better functional antibody immunogenicity as compared to systemic injection.

This study shows that low-dose adenovirus vaccines administered via microneedle patches to the skin induce better functional antibody responses than systemic injection.

Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

This study shows that SARS-CoV-2 spike glycoprotein does not directly interact with human basigin (CD147), challenging its role as a co-receptor for viral entry.

Structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site

The paper determines the structure of the RH5-binding region of P113 and identifies the binding site, providing insights for malaria vaccine development.

Rapid and iterative genome editing in the zoonotic malaria parasite Plasmodium knowlesi: New tools for P. vivax research

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

This paper develops a simian-adenovirus-vectored rabies vaccine that can be thermostabilized and administered as a single dose, showing potent immunogenicity and potential for low-cost pre-exposure prophylaxis.