Author

T. G. Franklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. N. Pruneda· 3 shared J. V. Nguyen· 2 shared P. P. Geurink· 2 shared A. F. Schubert· 1 shared C. G. Roberts· 1 shared D. J. Sanderson· 1 shared D. Komander· 1 shared G. D. Warren· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

J. N. Pruneda

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3 papers

Recent·Most cited

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

T. G. Franklin, P. S. Brzovic, J. N. Pruneda

This study identifies and characterizes bacterial HECT-like E3 ligases, revealing structural insights into their polyUb ligation mechanism and specificity.

bioRxiv · Jun 5, 2023Biochemistry

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin, J. V. Nguyen, P. P. Geurink, T. Kubori, H. Nagai, J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

bioRxiv · May 11, 2022Biochemistry

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin, P. P. Geurink, C. G. Roberts, D. J. Sanderson, L. N. Miller, H. Ovaa, K. Hofmann, J. N. Pruneda, D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

bioRxiv · Mar 28, 2020Biochemistry