Author

J. V. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

J. N. Pruneda· 2 shared K. D. Corbett· 2 shared P. P. Geurink· 2 shared R. K. Lau· 2 shared T. G. Franklin· 2 shared Y. Gu· 2 shared A. C. Soupir· 1 shared A. E. Berglund· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

J. N. Pruneda

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Author profile →

5 papers

Recent·Most cited

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin, J. V. Nguyen, P. P. Geurink, T. Kubori, H. Nagai, J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

bioRxiv · May 11, 2022Biochemistry

A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

R. K. Lau, E. Enustun, Y. Gu, J. V. Nguyen, K. D. Corbett

The paper identifies a conserved signaling pathway in bacteria that activates CBASS immune systems in response to DNA damage through the regulation of CapH and CapP.

bioRxiv · Apr 27, 2022Biochemistry

Control of bacterial immune signaling by a WYL domain transcription factor

C. L. Blankenchip, J. V. Nguyen, R. K. Lau, Q. Ye, Y. Gu, K. D. Corbett

The paper identifies CapW, a transcription factor that regulates CBASS gene expression in bacteria, showing it represses the system in uninfected cells and is activated by phage infection, though not required for anti-phage activity.

bioRxiv · Jan 4, 2022Biophysics

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin, P. P. Geurink, C. G. Roberts, D. J. Sanderson, L. N. Miller, H. Ovaa, K. Hofmann, J. N. Pruneda, D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

bioRxiv · Mar 28, 2020Biochemistry